Close this search box.

Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI)

Renal Insufficiency Meets Stress

Patients with renal insufficiency undergoing cardiac surgery are at significant risk for developing CSA-AKI.1-5
Doctor and nurse talk with elderly patient in hospital

Renal Insufficiency

Surgical Stressors

Increased CSA-AKI Risk

Renal Insufficiency 

Renal Insufficiency
of cardiac surgery patients have renal insufficiency1-4
20 %

Compromised kidney function

A quarter of all cardiac surgery patients have compromised kidney function.1-4
eGFR < 60

Surgical Stressors

Surgical Stressors
of cardiac surgery patients experience renal stressors
95 %

Insults on the kidneys

Cardiac surgery is especially taxing for the kidneys of patients with renal insufficiency due to:

Increased CSA-AKI Risk

Poor Outcomes
of cardiac surgery patients with pre-existing CKD develop AKI5
up to 34 %

When the kidneys fail, the patient fails.

Acute kidney injury (AKI) in patients with renal insufficiency has a significant impact:

increase in cost of care5-8
2 x
risk of extended hospital stay9,10
5 x
operative mortality rate9
7 x
likelihood of dialysis*9
55 x

*When patients with a normal eGFR (>90) are compared to CKD 4 (<30) patients the incidence of new requirement for dialysis is 0.2% to 10.9%; 55x.

Caution – Investigational Device, Limited by United States Law to Investigational Use Only. Not available for sale in the United States.

The JuxtaFlow® Renal Assist Device (RAD)

Roivios is developing a first-of-its-kind treatment designed to prevent AKI in patients undergoing cardiac surgery with pre-existing renal insufficiency.

Learn about BIPASS-AKI

Find info about our clinical study

Meet our Team

See what makes us different

Contact Us

Connect with our team


  1. Bowdish ME, D’Agostino RS, Thourani VH, et al. STS Adult Cardiac Surgery Database: 2021 Update on Outcomes, Quality, and Research. Ann Thorac Surg. 2021;111(6):1770-1780.
  2. Robert AM, Kramer RS, Dacey LJ, et al. Cardiac surgery-associated acute kidney injury: a comparison of two consensus criteria. Ann Thorac Surg. 2010;90(6):1939-1943.
  3. Palomba H, de Castro I, Neto AL, Lage S, Yu L. Acute kidney injury prediction following elective cardiac surgery: AKICS Score. Kidney Int. 2007;72(5):624-631.
  4. Brown JR, Kramer RS, Coca SG, Parikh CR. Duration of acute kidney injury impacts long-term survival after cardiac surgery. Ann Thorac Surg. 2010;90(4):1142-1148.
  5. Shen W, Aguilar R, Montero AR, et al. Acute Kidney Injury and In-Hospital Mortality after Coronary Artery Bypass Graft versus Percutaneous Coronary Intervention: A Nationwide Study. Am J Nephrol. 2017;45(3):217-225.
  6. LaPar DJ, Rich JB, Isbell JM, et al. Preoperative Renal Function Predicts Hospital Costs and Length of Stay in Coronary Artery Bypass Grafting. Ann Thorac Surg. 2016;101(2):606-612.
  7. HCUPnet, Healthcare Cost and Utilization Project. Agency for Healthcare Research and Quality, Rockville, MD.
  8. Hobson C, Ozrazgat-Baslanti T, Kuxhausen A, et al. Cost and Mortality Associated With Postoperative Acute Kidney Injury. Ann Surg. 2015;261(6):1207-1214.
  9. Cooper WA, O’Brien SM, Thourani VH, et al. Impact of renal dysfunction on outcomes of coronary artery bypass surgery: results from the Society of Thoracic Surgeons National Adult Cardiac Database. Circulation. 2006;113(8):1063-1070.
  10. Griffin BR, Bronsert M, Reece TB, et al. Creatinine elevations from baseline at the time of cardiac surgery are associated with postoperative complications. J Thorac Cardiovasc Surg. 2022;163(4):1378-1387.